synergistic combination drug
Independent studies using this MCP in combination with other drugs, treatments, herbal formulas, and more, show its remarkable ability to significantly increase the benefits of these therapies—with profound implications in the treatment of life-threatening diseases. 2012 Jul;36(7):601-10. Herein, two clinical small molecular drugs, celastrol (CST) and doxorubicin (DOX), were self-assembled into carrier-free and biocompatible nanoparticles (CST/DOX NPs) via a simple and green precipitation method for synergistic combination chemotherapy to overcome DOX resistance. These two formulas for breast and prostate cancer have both been shown in multiple studies to reduce tumor growth and prevent metastasis. Tehranian N, Sepehri H, Mehdipour P, Biramijamal F, Hossein-Nezhad A, Sarrafnejad A, Hajizadeh E. Cell Biol Int. 5. If we can find a way to make life-saving treatments more effective, at lower doses (meaning fewer side effects), it can be a game-changer, especially for patients with limited options. In other words, the whole is greater than the sum of its parts. By continuing you agree to the use of cookies. 1. Glioblastoma (GBM) is a highly aggressive and heterogeneous form of brain cancer. We use cookies to help provide and enhance our service and tailor content and ads. formally request permission using Copyright Clearance Center. The synergistic potential is unlimited. of the whole article in a thesis or dissertation. Please enable JavaScript DrEliaz.org is a free online health education resource based on Dr. Isaac Eliaz’s principles of patient-driven integrative medicine.
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2013;14(12):7561-8. Pectasol-C Modified Citrus Pectin targets Galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids. A subsequent cell study in 2019 showed similar results.2,3, Enhancing the effectiveness of chemo drugs is not the only synergistic benefit of MCP in cancer. 3. Certain natural ingredients demonstrate greater synergistic abilities than others. Traditional herbal systems around the world are well-versed in this concept and rely on the wisdom of strategic ingredient combinations to create powerful formulas. is available on our Permission Requests page. Med Chem. (please select at least one option), Live-Fermented Botanical Pre + Probiotic Elixir, Cardiovascular and Circulatory Health Research. One cell study showed that the combination of MCP with the antibiotic drug, cefotaxime, produced greater efficacy against methicillin-resistant Staphylococcus aureus (MRSA) strains. Fetching data from CrossRef. For example, MCP is shown in research to enhance the cancer-fighting actions of two researched botanical formulas — one for breast cancer and one for prostate cancer. Combination effect of PectaSol and Doxorubicin on viability, cell cycle arrest and apoptosis in DU-145 and LNCaP prostate cancer cell lines. Thus, CST/DOX NPs provide an alternative for overcoming drug resistance in future clinical applications. Thousands of studies show that out-of-control Gal-3 drives nearly every inflammatory, degenerative disease process — from cancer and infections to heart disease, obesity, neurological disease, and much more. In medicine, synergy is when a combination of two or more things — such as drugs, natural compounds, therapies, and treatments — produces significantly greater results compared to using each one alone.
Combination interstitial therapy of both paclitaxel and everolimus significantly reduced GBM growth and improved progression free survival in two clinically relevant orthotopic models of GBM resection and recurrence. with the reproduced material. If you are the author of this article you do not need to formally request permission Ramachandran C, Wilk B, Melnick SJ, Eliaz I. Evid Based Complement Alternat Med. Hossein G, Keshavarz M, Ahmadi S, Naderi N. Asian Pac J Cancer Prev. And more importantly, how can it benefit your health? Conti S, Vexler A, Hagoel L, Kalich-Philosoph L, Corn BW, Honig N, Shtraus N, Meir Y, Ron I, Eliaz I, Lev-Ari S. Integr Cancer Ther. One important cell study showed that MCP made prostate cancer cells more sensitive to radiation treatment. Ideal drug candidates for interstitial therapy are those that are potent against GBM and work in combination with both standard-of-care therapy and new precision medicine targets. Similarly, eating broccoli with tomatoes is shown to enhance the disease-fighting effects of both vegetables. to access the full features of the site or access our. Synergistic treatment combinations are also key to successful integrative medicine—the integration of diverse medical systems and approaches to achieve optimal results. Tested against a panel of GBM cell lines in vitro, paclitaxel was found to be effective at nanomolar concentrations, complement therapy with temozolomide, and synergize strongly with everolimus. It could even equal 100 or more.
Finally, synergistic combination chemotherapy was attained in both MCF-7/MDR cells and 3D multicellular tumor spheroids. 4. 2017;13(7):682-688. Thus, CST/DOX NPs provide an alternative for overcoming drug resistance in future clinical applications. Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer. Modified Citrus Pectin enhances chemotherapy, even against resistant cancers, and protects against damage from radiation treatment. In all cases the Ref.
Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer. Data shows the ability of MCP to increase the effectiveness of these treatments, allowing for lower dosages with greater benefits. Combination chemotherapy could overcome drug resistance; however, GBM's location behind the blood-brain barrier severely limits chemotherapeutic options. © 2020 Elsevier B.V. All rights reserved. it in a third party non-RSC publication you must Modified Citrus Pectin’s benefits extend far beyond cancer, as new research continues to expand the number of conditions where MCP can make a life-changing difference. contained in this article in third party publications Or, more simply put, one plus one equals more than two when you have synergistic activity. Hossein G, Halvaei S, Heidarian Y, Dehghani-Ghobadi Z, Hassani M, Hosseini H, Naderi N, Sheikh Hassani S. Cancer Med. Of the six drug combinations tested, we found that the combination of afatinib and YM155 was synergistically cytotoxic across four basal-like TNBC PDXs, and this drug combination significantly reduced PDX mammary tumor growth in vivo, without observable toxicity. 2017;2017:8379843. The combination of nitazoxanide, an FDA-approved drug, and remdesivir, FDA emergency use authorization for the treatment of COVID-19, demonstrate a strong synergistic interaction.
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